Association of Computed Tomography Densitometry with Disease Severity, Functional Decline, and Survival in SSc-ILD.

RATIONALE: Measuring disease extent and progression of systemic sclerosis-associated interstitial lung disease (SSc-ILD) is challenging, with recent studies suggesting potential utility of quantitative measurements from computed tomography (CT) scans. OBJECTIVE: To determine the associations of quantitative computed tomography (qCT) density-based measures with physiological parameters, visual CT scores, and survival in patients with SSc-ILD. METHODS: Patients with SSc-ILD and volumetric high-resolution CT images with