Juvenile dermatomyositis: treatment with intravenous gammaglobulin

Summary High-dose intravenous gammaglobulin (IVGG) has proved to be effective in the treatment of a number of immune disorders. We report two patients with juvenile dermatomyositis (DM) who improved with IVGG therapy. These patients had become refractory to corticosteroids and had developed unacceptable steroid toxicity. We suggest that IVGG can be useful in the treatment of juvenile DM. by reducing steroid requirements, and replacing immunosuppressive drugs.