Comparison of Na~(188)ReO_4,~(188)Re-DTPA and ~(188)Re-MAG_3 on Biodistribution and Excretion of Animal

In order to screen out an ideal radioactive agent for preventing the restenosis after PTCA(Percutaneous Transluminal Coronary Angioplasty),Na~(188)ReO_4,~(188)Re-DTPA and ~(188)Re-MAG_3 are injected into ICR mice and SD rats to compare the biodistribution and excretion.The experimental data show that the blood clearance of ~(188)Re-MAG_3 is much faster,and the uptake in tissues is obviously lower than Na~(188)ReO_4 and ~(188)Re-DTPA.At 2 h after injection,77.28% of injection dose of ~(188)Re-MAG_3 is excreted from urine,whereas less than 50% for Na~(188)ReO_4 and ~(188)Re-DTPA.So,~(188)Re-MAG_3 is a better candidate for balloon dilation providing uniform endovascular irradiation following PTCA for restenosis therapy.