Imidazolidinyl- or thiazolidinyl-containing 1,3,4-thiadiazole compounds and preparation method thereof
2011
The invention discloses imidazolidinyl- or thiazolidinyl-containing 1,3,4-thiadiazole compounds and a preparation method thereof, and belongs to the technical field of organic synthesis. The invention is characterized in that: amino substituted 1,3,4-thiadiazole compounds are subjected to chloracetyl formation, and by utilizing a characteristic that tautomers of thiocyanate ions have different stabilities at different temperatures, cyclization reaction can be performed by controlling reaction conditions and the imidazolidinyl- and thiazolidinyl-containing 1,3,4-thiadiazole compounds are prepared. The invention has the advantage that: according to requirements, the imidazolidinyl- and thiazolidinyl-containing 1,3,4-thiadiazole compounds can be selectively developed from the amino substituted 1,3,4-thiadiazole compounds.
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