Содержание витамина К1 в пуповинной крови новорожденных г. Архангельска

The optimal course of biochemical processes needs adequate dietary intake of vitamins involved in the body’s metabolic reactions. The basis for the pathogenesis of neonatal hemorrhagic disease is deficiency of vitamin K, the level of which in the North-Western Region of Russia was estimated for the first time. Objective: to measure umbilical cord blood vitamin K1 levels in newborn infants. Methods. Forty full-term newborns were examined. Vitamin K1 levels were determined using high performance liquid chromatography-tandem mass spectrometry. Results. The mean umbilical blood cord level of vitamin K1 was very low and amounted to 0.05 (<0.03; 0.15) µg/l. This study revealed no relationship between the level of the above trace element and neonatal sex (p=0,854), maternal age (p=0,913), abortions (p=0,568), threatened abortion (p=0,109), smoking (p=0,923). Conclusion. The umbilical cord blood concentration of vitamin K1 in the newborns was found to be very low, which increases the risk of hemorrhagic disease and requires exogenous replenishment of the above vitamin after birth.