Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors.

P.C. Lara,M. Lloret,Bernardino Clavo,Rosa María Cáceres Apolinario,Elisa Bordón,Agustín Rey,Orlando Falcón,Ana Ruiz Alonso,Claus Belka

Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors.

2008

P.C. Lara
M. Lloret
Bernardino Clavo
Rosa María Cáceres Apolinario
Elisa Bordón
Agustín Rey
Orlando Falcón
Ana Ruiz Alonso
Claus Belka

Hypoxia may inhibits the NHEJ DNA repair through downregulating Ku70/80 expression and combined with an increased angiogenesis and altered p53 expression would be responsible for tumor progression in cervical carcinoma.

Keywords:

Angiogenesis
Carcinoma
Hypoxia (medical)
DNA repair
Cancer research
Tumor progression
Cervical cancer
Medicine
Ku70
Oncology
p53 expression
Internal medicine
cervical carcinoma

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