Epithelial and Mixed Epithelial/Mesenchymal Malignancies of the Uterine Corpus

Cancers of the uterine corpus are the most frequently diagnosed malignancies of the female genital tract in the United States, with an estimated 61,880 new cases and 12,160 associated deaths expected for 2019. Endometrial carcinomas, which represent more than 95% of uterine corpus cancers, are heterogeneous as a group, and have been shown to be classifiable into clinically relevant subsets using morphological/immunophenotypic and molecular modalities. The recognized histotypes encapsulate the biologic profiles of the subclasses, albeit imperfectly, and accordingly continue to serve as a surrogate indicator for defining these clinically relevant subsets. This chapter illustrates the most salient pathologic features of epithelial and mixed epithelial/mesenchymal malignancies of the uterine corpus, with an emphasis on core appearances, morphologic variations, and immunophenotypic features.