Study of genetic susceptibility to the development of arterial hypertension in children in northwestern Russia

Using PCR-RFLP analysis of the frequencies of gene variants, CYP2J2,CYP4A11, and PTGIS, involved in the metabolism of arachidonic acid, were investigated in a group of children with fundamental arterial hypertension and a control group of children in Northwestern Russia. Also, alleles and genotype frequencies of gene variants CDH13, MTHFR, and CDKN2DAS, as well as the locus rs11191548, which were selected earlier due to their association with the development of arterial hypertension by GWAS in Europe and the United States in 2009, were analyzed. No association of any of the investigated markers with the development of arterial hypertension was confirmed.