MULTIVARIATE STEPWISE LOGISTIC REGRESSION ANALYSIS ON RISK FACTORS OF VENTILATOR-ASSOCIATED PNEUMONIA IN COMPREHENSIVE ICU

Objective To investigate the incidence, crude mortality and independent risk factors of ventilator-associated pneumonia (VAP) in comprehensive ICU in China.Methods The clinical and microbiological data were retrospectively collected and analysed of all the 97 patients receiving mechanical ventilation (>48hr) in our comprehensive ICU during 1999. 1 - 2000. 12. Firstly several statistically significant risk factors were screened out with univariate analysis, then independent risk factors were determined with multivariate stepwise logistic regression analysis.Results The incidence of VAP was 54. 64% (15. 60 cases per 1000 ventilation days), the crude mortality 47.42% . Interval between the establishment of artificial airway and diagnosis of VAP was 6.9 ± 4.3 d. Univariate analysis suggested that indwelling naso-gastric tube, corticosteroid, acid inhibitor, third-generation cephalosporin/ imipenem, non - infection lung disease, and extrapulmonary infection were the statistically significant risk factors of