High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

Manon Schulz,Cigdem Atay,Jessica Heringer,Franziska K. Romrig,Sarah Schwitalla,Begüm Aydin,Paul K. Ziegler,Julia Varga,W Reindl,Claudia Pommerenke,Gabriela Salinas-Riester,Andreas Böck,Carl Alpert,Michael Blaut,Sara C. Polson,Lydia Brandl,Thomas Kirchner,Florian R. Greten,Shawn W. Polson,Melek C. Arkan

High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

2014

A high-fat diet promotes intestinal tumorigenesis independently of obesity in a mouse model with oncogene activation, by changing the composition of the gut microbiota and altering immune regulation.

Keywords:

Intestinal Neoplasm
Obesity
Gut flora
Cancer
Immune system
Dysbiosis
Oncogene Activation
Immunology
Carcinogenesis
Biology
normal diet
intestinal mucosa
Pattern recognition receptor

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