P423 Genetic and polysomnographic characteristics of Korean patients with narcolepsy or obstructive sleep apnea syndrome

mal pregnant women (control), underwent overnight pulse oximetry and nasal pressure measurements (Embletta,Medcare) at mean gestation of 31 weeks.We applied The American College of Obstetricians and Gynecologists definitions for pre-eclampsia. Fasting blood samples were drawn for Tumor Necrosing Factor alpha (TNFa), Interleukin 6 (IL-6) and sensitive C Reactive Protein (CRP). Data from clinical evaluation of edema by analog scale (0 = no, 12 = severe edema), pregnancy outcomes, Epworth sleepiness scales (ESS) and Tiredness questionnaire (0 = no, 3 = severe) were collected. Results:No significant differences in age, body mass index (BMI) at sleep study, gestational age, bloodoxygen saturation (SpO2) or ESS were found between PE and controls. The nasal flow was significantly limited in PE women (Table 1), theywere significantly (p < 0.01)more tired than controls, mean (SD) 1.4 (0.5) vs. 0.1 (0.5), and had worse pregnancy outcomes (p < 0.05): 1-min Appgar score 7.9 (1.8) vs. 8.8 (0.4), relative birth weight (z-score) 1.9 (0.8) vs. +0.4 (1.2). The table shows the main findings: Conclusions: Pregnant women with pre-eclampsia showed significantly more nasal flow limitation during the night, higher fasting IL-6 and TNFa plasma levels, more edema and worse pregnancy outcomes than healthy pregnant women.