A novel synthesis of ethyl carbonate derivatives of β-cyclodextrin.

Abstract The carbonate ester derivatives of β-cyclodextrin play a very important role in several fields, such as catalytic reaction and enantiomer separation. In this work, a novel synthesis process of the β-cyclodextrin carbonate ester has been investigated through the reaction between β-cyclodextrin and diethyl carbonate with anhydrous potassium carbonate as catalyst. The compounds were separated by semi-preparative chromatography and characterized by FT-IR, MS, 1 H NMR, and 13 C NMR spectroscopy. The position of the substituent was confirmed by 13 C NMR and this conclusion coincides with the analyses of MS and 1 H NMR in the main. The yield of the mono-6-O-ethoxycarbonyl β-CD is 65.8%.