Unusual Hypersensitivity Reaction to Iohexol During Epidural Steroid Injection Resulting in Lipoma Development: A Case Presentation

Abstract Epidural steroid injections are common interventional pain procedures for radicular pain when conservative therapies fail. We present the case of a 36-year-old woman with lumbar radicular pain who developed a hypersensitivity reaction to iohexol during a fluoroscopically guided interlaminar epidural steroid injection resulting in lipoma development. Mechanisms of anaphylactoid reaction and recommendations for lipoma treatment are described based on clinical presentation. With an increase in the number of injections performed for pain management, awareness of this complication may need to be included for informed consent. Level of Evidence V