Is cancer an independent risk factor for fatal outcomes of coronavirus disease 2019 patients?: Cancer and fatal outcomes in COVID-19 patients

Background : Coronavirus disease 2019 (COVID-19), caused by a novel virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought new challenges for global health systems Objective : The objective of this study was to investigate whether pre-diagnosed cancer was an independent risk factor for fatal outcomes of coronavirus disease 2019 (COVID-19) patients Method : A comprehensive search was conducted in major databases of PubMed, Web of Science, and EMBASE to identify all published full-text studies as of January 20, 2021 Inter-study heterogeneity was assessed using Cochran's Q-statistic and I² test A meta-analysis of random- or fixed-effects model was used to estimate the effect size Publication bias, sensitivity analysis and subgroup analysis were also carried out Results : The confounders-adjusted pooled effects (pooled odds ratio [OR] = 1 47, 95% confidence interval [CI]: 1 31–1 65;pooled hazard ratio [HR] = 1 37, 95% CI: 1 21–1 54) indicated that COVID-19 patients with pre-diagnosed cancer were more likely to progress to fatal outcomes based on 96 articles with 6,518,992 COVID-19 patients Further subgroup analyses by age, sample size, the proportion of males, region, study design and quality rating exhibited consistent findings with the overall effect size Conclusion : Our analysis provides the objective findings based on the adjusted effect estimates that pre-diagnosed cancer is an independent risk factor for fatal outcome of COVID-19 patients During the current COVID-19 pandemic, health workers should pay particular attention to cancer care for cancer patients and should prioritize cancer patients for vaccination