INHIBITION OF HUMAN ERYTHROCYTE AND GASTRODUODENAL CATECHOL-O-METHYLTRANSFERASE ACTIVITY BY NITECAPONE

The effect of increasing single oral doses of the novel catechol-O-methyltransferase (COMT) inhibitor, nitecapone, on enzyme activity in red cells (RBC) and gastroduodenal COMT activity has been studied in healthy male volunteers.