Visible Light-Mediated Atom Transfer Radical Addition of Styrene: Base Controlled Selective (Phenylsulfonyl)difluoromethylation

The first example of visible light-mediated atom transfer radical addition reaction of (phenylsulfonyl)difluoromethyl iodide to styrenes has been reported. By simply tuning the organic or inorganic bases in the reaction system, both ATRA and heck-type products could be afforded with high selectivity. This method has demonstrated mild conditions, high catalytic reactivity, excellent chemoselectivity and broad substrate scope. Besides, it offers a new solution for difunctionalization of alkenes to synthesize diverse difluoromethylated molecules after simple work-up.