EFFECT OF IL2 ACTION BY IMMUNOSUPPRESSIVE FACTOR PRODUCED BY LEUKEMIA CELL

Leukenia cell lines produces a tumor-derived immunosuppressive factor(TDSF)、which inhibited the proluction of IL2 after action on PBMC for 6 h The responseof PBMC treated with PHA-p to exogeneous IL2 was significantly decreased in the presenceof TDSF,suggesting that TDSF can inhibit the acion of IL2.The effect of PBMC afterbeing stimulated with PHA-P was significantly suppressed by TDSF in dose-dependent manner。These findings suggest that the inhibitory a dion of TDSF on T cell activation and proliferationassociated with IL2.The synthesis and secretion of TDSF in acute non-lymphocytic leuke miawere partially inhibited by anticancer drugs.