Abstract 15273: Combined Impact of Chronic Kidney Disease and Acute Kidney Injury on Long-Term Mortality in Patients With Acute Myocardial Infarction - The J-MINUET Substudy -

Introduction: Renal dysfunction such as chronic kidney disease (CKD) as well as acute kidney injury (AKI) is associated with poor outcomes after acute myocardial infarction (AMI). We examined the combined impact of CKD and AKI on long-term mortality in patients with AMI. Hypothesis: Both CKD and AKI, i.e., acute-on-chronic kidney injury, might amplify the increased risk of mortality after AMI. Methods: J-MINUET is a prospective, multicenter registry that enrolled consecutive AMI patients who were admitted within 48 h after symptom onset between July 2012 and March 2014 at 28 hospitals in Japan. We studied serum creatinine (Cr) during hospitalization in 2811 patients who underwent urgent coronary angiography from this registry. CKD was defined as estimated glomerular filtration rate on admission <60 ml/min/1.73m2, and AKI was defined as Cr increase ≥0.3 mg/dl or ≥50% within 48h during hospitalization. Results: The incidences of CKD and AKI were 40% and 10%, respectively. AKI developed more frequently in CK...