Rivaroxaban intermediate impurities and preparation and separation and purification methods thereof

The invention belongs to the field of pharmaceutical synthesis, and particularly discloses Rivaroxaban intermediate impurities R6-1 and R6-2 and preparation and separation and purification methods thereof. The preparation method comprises the steps that 2.2'-(2R,2'R)-3,3'-(4-(3-oxomorpholine)phenyldiazane)bis(2-hydroxyl propane-3,1-diyl)isoindole-1,3-diketone(R5-1) is taken as a starting material to react with N,N'-carbonyldiimidazole, a mixture of the R6-1 and the R6-2 is generated, the mixture is separated and purified through a prepared chromatographic column, and then the high-purity R6-1 and R6-2 can be obtained. The R6-1 and the R6-2 can serve as reference substances of Rivaroxaban intermediate impurity detection and have the important significance for monitoring the purity of an intermediate to control a final product.