Significance of detecting oxidized low density lipoprotein level in patients with type 2 diabetes mellitus and diabetic nephropathy

Objective To investigate the concentration change and clinical significance of oxidized low density lipoprotein (ox-LDL) level in patients with type 2 diabetes mellitus(T2DM) and diabetic nephropathy(DN).Methods According to urinary albumin excretion rate(UAER),115 T2DM cases were divided into simple diabetic mellitus(SDM,46 cases),early diabetic nephropathy(EDN,40 cases) and clinical diabetic nephropathy(CDN,29 cases).Another 30 healthy persons were taken as the controls(group NC).Blood level of ox-LDL was examined by ELISA with double antibody sandwich method.Results Compared with group NC,plasma levels of ox-LDL,ox-LDL/LDL-C and high sensitive C-reactive protein(hsCRP) in groups of SDM,EDN and CDN were significantly increased(P0.05),which was more obvious as pathogenetic condition aggravated.ox-LDL was positively correlated with hsCRP(r=0.83,P0.01).ox-LDL level increased as micro-albuminuria increased in T2DM patients.Conclusion The level of ox-LDL is increased in patients with T2DM,which may be taken as an early sensitive diagnostic marker for DN.