An Automated Method for the Determination of Montelukast in Human Plasma Using Dual-Column HPLC Analysis and Peak Height Summation of the Parent Compound and Its Photodegradation Product

Glenn Smith,Cynthia M. Rawls,Robert L. Kunka

An Automated Method for the Determination of Montelukast in Human Plasma Using Dual-Column HPLC Analysis and Peak Height Summation of the Parent Compound and Its Photodegradation Product

2004

Glenn Smith
Cynthia M. Rawls
Robert L. Kunka

Purpose. To develop an assay to evaluate the bioequivalence of overcoated and marketed montelukast formulations, the former to be used for future blinded clinical studies.

Keywords:

Montelukast
Bioequivalence
High-performance liquid chromatography
Photodegradation
Chromatography
Analytical chemistry
Chemistry
dual column
automated method
hplc analysis
human plasma

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