How host metabolism impacts on virus pathogenesis

The outcome of virus infections depends on multiple factors. This review deals with the role of host metabolism as one such factor. We describe how different cells in the immune system employ differential metabolic pathways and how this relates to the outcome of virus infections. We also discuss how nutritional and metabolic diseases can influence the nature of viral pathogenesis as well as how targeted therapies against metabolic processes can impact on the outcome of virus infections. The case is also made for metabolic profiling as a potential tool to predict the outcome of a virus infection and to guide therapies that enhance host resistance.