Rivaroxaban intermediate and method for synthesizing rivaroxaban by same
2011
The invention discloses a rivaroxaban intermediate shown as a formula III, and a synthesis method thereof, and discloses application of the rivaroxaban intermediate in synthesis of rivaroxaban. A nuclear structure of the rivaroxaban is constructed by a two-reaction step; the rivaroxaban has high stereoselectivity; in the operating process, rigorous conditions of low temperature, no water, no oxygen and the like are not needed; and the operation is simple and convenient, the atom utilization rate is high, the environment is protected, the production cost is low, and the method is suitable for industrial production.
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