Ligand-Enabled Gold-Catalyzed 1,2-Heteroarylation of Alkenes

By adopting the interplay of ligand-enabled Au(I)/Au(III) catalysis and the unique π-activation mode of gold complexes, a highly underscored 1,2-heteroarylation of alkenes has been accomplished. The present ligand-enabled approach not only circumvents the requirement of strong sacrificial oxidants or photocatalysts but also operates under mild reaction conditions by utilizing simple and non-prefunctionalized aryl coupling partners. The reaction offers an excellent chemo-, regio-, and stereoselective platform to achieve the desired two-component as well as more challenging three-component 1,2-oxy, and 1,2-aminoarylation of alkenes.