Late sequelae of localized neuroblastoma presenting with epidural compression. A study of the Italian and French Neuroblastoma Groups

10053 Background: Symptomatic epidural spinal cord compression (EC) occurs in 5–10% of neuroblastoma (NB) patients at presentation. Survival is excellent, but sequelae of EC can be severe. Severity of motor impairment at presentation correlates with probability of neurological recovery, and chemotherapy (CT) and neurosurgery (NS) have been shown to be equally effective in relieving EC. However, so far only few studies focused on late sequelae of EC, mainly scoliosis. Methods: We retrospectively reviewed a cohort of children with localized NB, presenting with EC and surviving more than 2 years from time of diagnosis, to report late sequelae and correlate them with clinical features and tumour’s characteristics at diagnosis, and treatment. Chi-squared test, Odd-ratios and 95% confidence intervals were applied for statistical analysis. P<0.05 was considered statistically significant. Results: 102 eligible children were identified in the Italian and French NB Registries, and for 98 adequate information was av...