Open fetal spinal cord surgery in rats with low mortality achieved by prevention of oligohydramnios

Abstract Myclotomies were performed with an open microsurgical technique in rat fetuses aged between E16 and E18. In 87 consecutively treated fetuses the net surgical mortality was as low as 7%. The cause of death due to fetal surgery is shown to be amniotic fluid loss. The high survival rate is attributed to the prevention of oligohydramnios. The technique is described in detail and the results are discussed.