Association between aflatoxin exposure and health characteristics, liver function, hepatitis and malaria infections in Ghanaians

Purpose. We examined the relationship between various health parameters and aflatoxin B1 (AFB1) albumin adduct levels in plasma.Design. A cross‐sectional field study was conducted in four villages in the Ashanti region of Ghana.Methods. A survey on socio‐demographic and health characteristics was administered to 162 volunteers and blood (20 ml) was donated by 140 participants. AFB1 albumin adduct levels, liver function, hepatitis B and C viruses (HBV, HCV) and malaria infections were determined.Results. AFB1 levels ranged from 0.12 to 2.995 pmol mg−1 albumin (mean±standard deviation = 0.89±0.46) and was categorized based on the median as low (<0.80 pmol mg−1) or high (⩾0.80 pmol mg−1) and used in the analyses. By multivariate analysis, significantly higher levels of AFB1 were obtained for participants who reported symptoms of acute aflatoxicosis: history of yellow mouth (odds ratio = 5.5, confidence interval = 1.04–29.07, p = 0.04); history of sore swollen stomach (odds ratio = 4.54, confidence interval =...