Natural Killer Cell Inspired AIE Nanoterminator for Blood-Brain-Barrier Crossing via Tight-Junction Modulation and NIR-II Gliomas Theranostics
2020
Nature has always inspired
robotic designs and concepts. It is conceivable that biomimic nanorobots will
soon play a prominent role in medicine. In this paper, we developed a natural
killer cell-mimic AIE nanoterminator (NK@AIEdots) by coating natural kill cell
membrane on the AIE-active polymeric endoskeleton, PBPTV, a highly bright
NIR-II AIE-active conjugated polymer. Owning to the AIE and soft-matter
characteristics of PBPTV, as-prepared nanoterminator maintained the superior
NIR-II brightness (quantum yield ~8%) and good biocompatibility. Besides, they
could serve as tight junctions (TJs) modulator to trigger an intracellular
signaling cascade, causing TJs disruption and actin cytoskeleton reorganization
to form intercellular “green channel” to help themselves crossing Blood-Brain
Barriers (BBB) silently. Furthermore, they could initiatively accumulate to
glioblastoma cells in the complex brain matrix for high-contrast and
through-skull tumor imaging. The tumor growth was also greatly inhibited by
these nanoterminator under the NIR light illumination. As far as we known, The
QY of PBPTV is the highest among the existing NIR-II luminescent conjugated
polymers. Besides, the NK-cell biomimetic nanorobots will open new avenue for
BBB-crossing delivery.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
41
References
0
Citations
NaN
KQI