Inhibition of feline immunodeficiency virus (FIV) replication by DNA binding polyamides

Sanjay K. Sharma,Jean-Noel Billaud,Manju Tandon,Olivier Billet,Sam J. Choi,Mary L. Kopka,Tom R. Phillips,J. William Lown

Inhibition of feline immunodeficiency virus (FIV) replication by DNA binding polyamides

2002

Sanjay K. Sharma
Jean-Noel Billaud
Manju Tandon
Olivier Billet
Sam J. Choi
Mary L. Kopka
Tom R. Phillips
J. William Lown

Two DNA minor-groove binding polyamides 1 and 2 were designed and synthesized and evaluated for inhibition of FIV-34TF10 replication. Both 1 and 2 decreased the replication of FIV-34TF10 by 75% by acting at the level of the virus but outside of the LTR or env region.

Keywords:

Chemical synthesis
Viral replication
Virus
DNA
Organic chemistry
Biochemistry
Feline immunodeficiency virus
Lentivirus
Oligomer
In vitro
Chemistry
Feline immunodeficiency virus FIV
tertiary amine

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