Role of the I,, protein in the LinK channel complex

or HEK293 cells. The quaternary structure of the lmlnK channel complex has long remained a mystery, but recent studies suggest an interaction of the Isx protein with a traditional K+ channel subunit, identified in man as KvLQTl. It is unclear at this point what the mechanism of this interaction is, or whether the I,, protein may also interact with other ion channel subunits. However, there is an abundance of information regarding the role and regulation of the ISK protein in the IminK channel complex, discussed in this review by