Dermatological side effects of intravesical Mitomycin C: Delayed hypersensitivity.

2016 
espanolOBJETIVO: Conocer los efectos secundarios dermatologicos del tratamiento con Mitomicina C endovesical en el cancer de vejiga no musculo invasivo. METODOS: Se describen dos casos de dermatitis palmo plantar durante dicho tratamiento. RESULTADO: Se describen dos tipos de etiopatogenia en dermatitis durante el tratamiento con Mitomicina C endovesical, dermatitis por contacto y dermatitis por hipersensibilidad retardada. CONCLUSIONES: La dermatitis por contacto de etiologia no alergica es un efecto secundario frecuente, se han descrito muchos casos en la literatura, por otro lado existe la dermatitis por mecanismo de hipersensibilidad retardada tipo IV es mucho menos frecuente y requiere tratamiento con corticoesteroides. EnglishOBJECTIVE: To know the dermatologic side effects of intravesical treatment with Mitomycin C in non muscle invasive bladder cancer. METHODS: We describe two cases of palm and plantar dermatitis after such treatment. RESULT: We describe two types of dermatitis pathogenesis during treatment with intravesical Mitomycin C: contact dermatitis and delayed hypersensitivity dermatitis. CONCLUSIONS: Contact dermatitis of non-allergic origin is a common side effect described in many instances in the literature, on the other hand exists dermatitis secondary to delayed hypersensitivity type IV much less common, requiring treatment with corticosteroids.
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