Study of Various Poisoning: A Review

Organophosphate pesticides poisoning is a leading cause of morbidity and premature loss of life. Now those days it is very important factor in our life. Organophosphorus compound poisoning is a common cause of acute poisoning in India with high mortality, out of cause of death, an important are is respiratory failure. OPs cause toxicity after their absorption from skin, mucous membrane and respiratory tract following accidental exposures, or from gastrointestinal tract following suicidal ingestion. Organophosphorus compound are the chemical compound containing carbon-phosphorus bond. Poisoning with organophophorus compound may be i) Occupational ii) Accidental iii) Suicidal. The organophosphorus anti - chE agent are hydrolysed by two families of enzyme, carboxylesterases and paraoxonases, which are not inhibited by OP compounds. Discuss about the Pharmacokinetics, clinical feature of op compound poisoning The most widely used diagnostic tests for OP exposure are the estimation of plasma ( PchE) cholinesterase and red blood cells AchE activity. For treatment used Atropine as anti-cholinergic agent. activated charcoal can proven to be effective then it should be an extremely valuable theropy since if is widely available in the developing world. © 2011