N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
2010
Abstract A series of N 1-alkyl pyrimidinediones were designed, synthesized and evaluated as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Our efforts identified compound 10b , which represents the lead compound in this series with pharmacokinetics and antiviral potency that may support once-daily dosing.
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