Pharmacokinetics and Histopathological Findings of Chemoembolization Using Cisplatin Powder Mixed with Degradable Starch Microspheres in a Rabbit Liver Tumor Model

Takeshi Sato,Toshihiro Tanaka,Hideyuki Nishiofuku,Yasushi Fukuoka,Hiroshi Sakaguchi,Tetsuya Masada,Shota Tatsumoto,Nagaaki Marugami,Masato Takano,Ichiro Yamato,Masayuki Sho,Chiho Ohbayashi,Toshiko Hirai,Kimihiko Kichikawa

Pharmacokinetics and Histopathological Findings of Chemoembolization Using Cisplatin Powder Mixed with Degradable Starch Microspheres in a Rabbit Liver Tumor Model

2017

Takeshi Sato
Toshihiro Tanaka
Hideyuki Nishiofuku
Yasushi Fukuoka
Hiroshi Sakaguchi
Tetsuya Masada
Shota Tatsumoto
Nagaaki Marugami
Masato Takano
Ichiro Yamato
Masayuki Sho
Chiho Ohbayashi
Toshiko Hirai
Kimihiko Kichikawa

Purpose The purpose of this study is to evaluate the pharmacokinetics and histopathological findings of transarterial chemoembolization (TACE) using cisplatin powder mixed with degradable starch microspheres (DSM) (Cis/DSM-TACE) compared with cisplatin arterial infusion (Cis-AI).

Keywords:

Degradable starch microspheres
Apoptosis
Cisplatin
Starch
Microsphere
Pathology
Liver tumor
Pharmacokinetics
Medicine
Pharmacology
tumor cells
Radiology

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