Comment on “An unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using a zebrafish embryo model” by C. E. Puerto Galvis and V. V. Kouznetsov, Org. Biomol. Chem. , 2013, 11, 407

Fedor I. Zubkov,Elisaveta A. Kvyatkovskaya,E. V. Nikitina,P. N.-A. Amoyaw,Vladimir V. Kouznetsov,Vladimir A. Lazarenko,Victor N. Khrustalev

Comment on “An unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using a zebrafish embryo model” by C. E. Puerto Galvis and V. V. Kouznetsov, Org. Biomol. Chem. , 2013, 11, 407

2017

Fedor I. Zubkov
Elisaveta A. Kvyatkovskaya
E. V. Nikitina
P. N.-A. Amoyaw
Vladimir V. Kouznetsov
Vladimir A. Lazarenko
Victor N. Khrustalev

It has been proved that the reaction between furfuryl amines and N-R-maleimides leads to the formation of aza-Michael addition products – 3-(furylmethylamino)-N-R-pyrrolidine-2,5-diones, instead of 7-oxa-2-azabicyclo[2.2.1]hept-5-enes, as this journal reported previously.

Keywords:

Chemistry
Organic chemistry
Zebrafish
Ene reaction
Furfurylamine
Stereochemistry
zebrafish embryo

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