Endothelin-1 response to mental stress in early ischemic lesions of the extremities due to systemic sclerosis

Abstract We studied circulating levels of endothelin-1, catecholamines and nitric oxide after a mental arithmetic test in 14 patients with early ischemic lesions of the extremities due to systemic sclerosis and slightly impaired peripheral vascular flow. The test induced an increase ( P n  = 20) the test significantly ( P