Large cell transformation病巣が先行しHodgkin病と誤認された菌状息肉症

A 66-year-old male noticed erythemas on his thigh 16 years ago and later he noticed generalized erythemas 7 years ago. They were clinically diagnosed as asteatic eczema. He had an axillary subcutaneous tumor sized 10×5cm, which was histologically diagnosed as an acute inflammatory process. Because the tumor had persisted, it was resected and showed a proliferation of large cells, which led to a diagnosis of Hodgkin's disease. Thereafter, generalized erythrodermatous lesions succeeded and an indurated erythema was newly formed in his left shoulder after chemotherapy (ABVD) and irradiation (40Gy). The lesions were biopsied and were diagnosed as mycosis fungoides (MF) showing large cell transformation. Retrospectively, the axillary subcutaneous tumor was reevaluated and the proliferation of large cells noted there was histologically similar to the latter one, thus diagnosed as MF with large cell transformation. [Skin Cancer (Japan) 2004; 19: 167-172]