Renoprotective effect of Lycopene on Renal Functional and Histopathological changes in Gentamycin Induced Nephrotoxicity in Rats.

Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on renal function. There are various forms, and some drugs may affect renal function in more than one way. Nephrotoxins are substances displaying nephrotoxicity. The aim of this study is to explore the effect of lycopene inhibition in lesions of gentamicin-induced nephrotoxicity, Mature 24 male mature Sprague-Dawley rats were divided into 4 groups of 6, group1: control, group 2 sham received daily lycopene injection (200 mg/kg) for 12 days, group 3 received daily GS injection (100mg/kg) for 12 days, group 4 received daily GS (100 mg/kg) and lycopene injection (100mg/kg)) for 12 days. After 12 days, rats were anaesthetized, blood sample were obtained and kidneys were removed then stained with hematoxylin and eosin method and then were studied histophatologically. Serum creatinine and urea were measured. lycopene significantly decreased the levels of urea and creatinine in treated group compared with the nephrotoxic untreated group. treatment of nephrotoxic animals with lycopene could significantly inhibit leukocyte infiltration and tubular necrosis in comparison with the nephrotoxic untreated group the findings showed that lycopene alleviates loss of leukocyte infiltration and tubular necrosis and exerts beneficial effects on kidney function test in nephrotoxic group