Physical Activity and Angiotensin-Converting Enzyme Gene Polymorphism in Mild Hypertensives

It has been suggested that the insertion(I) allele of the I/deletion(D) polymorphism of the angiotensin converting enzyme (ACE) gene is associated with endurance exercise and increased physical conditioning in response to this type of exercise. To investigate the association between the ACE I/D polymorphism and physical activity status in 355 never treated, stage I hypertensives (265 men, 90 women, mean age: 33 � 9 years), in whom power exercise is contraindicated, participants of the HARVEST study. Physical activity was assessed using a standardized questionnaire. BMI and age did not vary among genotypes. None of active subjects performed power oriented exercises. ACEI/D frequencies (II-18%,ID-55%,DD-27%) were in Hardy–Weinberg equilibrium. Sedentary lifestyle was more common among DD than II hypertensives (76% in DD, and 48% in II, x 2 ¼ 13.9, P ¼ 0.001). In stepwise MANOVA using age, marital status, profession, sex, and ACE genotype as predictors of physical activity, marital status (F ¼ 24.4, P < 0.0001) and ACE genotype (F ¼ 16.03, P < 0.0001) contributed to more than 50% of the variance in physical activity status of the population. Our results suggest that theACE I/D polymorphism may be a specific genetic factor associated with physical activity levels in free-living borderline and mild hypertensive subjects. 2003 Wiley-Liss, Inc.