Double-chambered right ventricle in adults: invasive and noninvasive hemodynamic considerations

Abstract Background Data on the features of double-chambered right ventricular (DCRV) in adults are limited. It is also unclear how invasive and Doppler-derived assessments of right ventricular (RV) obstruction in DCRV correlate. Methods Retrospective review of 17 adults (age ≥18 years) diagnosed with DCRV who underwent right heart catheterization at Mayo Clinic, MN between 1990 and 2021. Clinical, echocardiographic, and invasive hemodynamics were abstracted from the medical charts. Results Mean age was 44±19 years and 7 (42%) patients were female. Two patients (13%) had undergone prior surgical repair of DCRV with ventricular septal defect (VSD) closure and had residual/recurrent obstruction; a VSD had been previously documented in 16 patients (94%). RV inflow to pulmonary artery systolic gradient at catheterization was 42 (19; 95) mmHg. The correlation coefficient between RV inflow to pulmonary artery systolic gradients and Doppler-derived peak gradients was 0.87 (p Conclusion Significant discrepancy between non-simultaneous echo-derived and invasively measured intracavitary RV gradients was seen in adults with DCRV. There was no correlation between the degree of RV obstruction and symptoms/functional capacity.