Formation of DNA adducts in wt and transgenic mice expressing human sulfotransferases after treatment with heterocyclic amines and furans

s / Toxicology Letters 229S (2014) S40–S252 S183 increased (20%) cell proliferation at lower concentration. No IC50 values were obtained. Combination of AOH+SSI no increased cytotoxicity respect AOH tested alone. ROS generation was determined by the H2-DCFDA probe up to 120min. The ROS produced by AOH (15, 30 and 60 M) was 1.2-fold higher than the control. While SSI (6.25, 12.5 and 25 M) and the combination of SSI (6.25 M)+AOH (15 M) did not produce ROS generation. In conclusion, the SSI decreased cytotoxicity produced by AOH. Thus, food commodities containing SSI (specially, legumes) could contribute to diminish the toxicological risk that natural contaminant as AOH in diet can produce to humans. http://dx.doi.org/10.1016/j.toxlet.2014.06.623