Nosocomial candidemia:clinical retrospective analysis

OBJECTIVE To analyze the risk factors,clinical manifestation and flora distribution of candidemia and provide a reference for clinical diagnosis and therapy.METHODS Totally 19 cases of candidemia in our hospital were analyzed retrospectively from Mar 2008 to May 2010.RESULTS 84.2% of patients with candidemia suffered from three or more underlying diseases.All of the patients with candidemia had four or more high risk factors.94.7% of patients with candidemia were placed catheter and 63.2% of patients with candidemia were confirmed CRBSI.Of these clinical manifestations,fever,elevated white cells and neutrophils,failure of liver,kidney and circulation and MODS were the main manifestations.The distribution of isolated Candida species were Candida albicans(47.4%),Candida glabrata(15.8%),Candida tropicalis(15.8%),Candida parapsilosis(15.8%) and Candida krusei(5.2%).Therapeutic measure included removing catheters and using antifungal agents.The cure rate of patients with candidemia was 63.2%.CONCLUSION Candidemia usually occurs in patients who suffered from multiple underlying diseases and with high risk factors,of which Candida albicans is the most common pathogen.