A Review on Graph Analytics-Based Approaches in Protein-Protein Interaction Network

Essential proteins play a vital role in the biological and cellular activity of a living organism. Identification of essential proteins is crucial for understanding the cellular life mechanisms for medical treatments and disease diagnosis. The existing computational measures are primarily based on identifying dense sub-graphs from the protein interaction network. In this research paper, the existing computational, graph theoretic approaches are reviewed and a novel research direction to find essential proteins is proposed.