Analysis of the results and prognostic factors after conservative treatment of anal canal cancer

Objective To analyze the long-term results and prognostic factors of the anal canal cancer after conservative treatment. Methods From 1984 to 2005,286 patients were treated by exclusive radiotherapy or chemoradiotherapy for an epidermoid cancer of anal canal. Results The mean follow-up was 65 months. The 5-year-overall survival and 5-year disease free survival rate were 66.4 % and 64.8 % respectively. In multivariate analysis, the tumor size( 75 %) to first course irradiation (RR 1.9) were factors for disease free survival (DFS). Five-year-locoreginal control rate (LRC) was 71.5 % (88 % for stage Ⅰ, 69 % for stage Ⅱ, 77 % for stage ⅢA and 60 % for stage ⅢB). Prognostic factors of LRC were tumor size (RR 2.5), response to first course of irradiation (RR 2.9). Conclusion The prognostic factors of the rate of LRC, DFS and global survival assessed by statistical analysis are clinical stage, tumor size and response to first course of irradiation. Key words: Anus neoplasms;  Carcinoma, squamous cell;  Colorectal surgery;  Radiotherapy;  Drug therapy;  Treatment outcome;  Prognosis