Preparation and Characteristics of Paclitaxel Submicroemulsion for Injection

Objective To prepare paclitaxel submicroemulsion for injection and investigate its physical-chemical properties.Methods A high pressure homogenizer was used to prepare paclitaxel submicroemulsion.The effect of different formulation and preparation factors on properties of paclitaxel submicroemulsion was evaluated.The possibility of vascular irritation was observed.Results Paclitaxel submicroemulsion for injection prepared using the optimal formula and technology had no vascular irritation and exhibited good particle size distribution and stability.The particle size,polydispersity index and zeta potential were(168±22) nm,(0.89±0.06)and-(33.9±0.5) mV,respectively.Conclusion Paclitaxel submicroemulsion for injection is well-designed in formula,reliable in technology,and easy to manufacture and use.