Vitamin D deficiency in asthma patients with allergic bronchopulmonary aspergillosis (ABPA)

Background : Vitamin D deficiency is being increasingly recognized in chronic lung disease. Recent studies suggest that ABPA correlated with vitamin D deficiency among Cystic Fibrosis (CF) patients, and that heightened Th2 reactivity in ABPA correlated with lower mean serum vitamin D levels. However, this correlation remains unknown in asthma patients with ABPA. Methods: 144 asthma patients (with ABPA, n=80), (without ABPA, n=64) who attended our hospital between January 2011 and May 2012 were prospectively evaluated for 25-hydroxyvitamin D (25-OHD3), lung function and IgE levels. Patients were retrospectively reviewed for clinical characteristics and prognosis compared with patients with normal VitD levels. Results: VitD deficiency ( ( CONCLUSION : Our data suggests that asthmatic ABPA patients may have higher vitamin D status than non-ABPA patients and that there may be an association between lung function and Vitamin D status. However, the causal effect relationship needs to be established.