Предоперационная динамика показателей артериального давления, эндотелиальной функции и цитокинового профиля у пациентов с холецистэктомией

Th e aim of the study was to evaluate the relationship of stress-induced violations of endothelial function and cytokine profi le with the indicators of arterial pressure's daily monitoring of the patients depending on the availability of syndrome of arterial hypertension (AH) before planned laparoscopic cholecystectomy. Th e analysis of stress-induced violations of homeostasis in 100 patients, admitted for laparoscopic cholecystectomy was performed. Th e clinical characteristic of patients with assessment of markers of humoral regulation, endothelial function, infl ammation, and their relationship with the DMAP (the daily indicators of arterial pressure monitoring) is shown. Patients were divided into 2 groups depending on the presence of arterial hypertension. Patients with AH before surgery, compared with the indicators, evaluated for 2 weeks before the planned hospitalization, aggravated manifestations of hypertensive syndrome, according to the DMAP, recorded increase in endothelin and proinfl ammatory cytokines interleukin 6 and 8, as well as reducing anti-interleukin 10, in contrast to the patients without AH. Patients with AH before operation have classic stress syndrome, characterized by not only high arterial pressure, heart rate, especially on the eve of the operation, but also an imbalance of pro-and antiinfl ammatory cytokine profi le, increased endothelin, with respect to the patients without AH.