A RECENT REVIEW ON ALTERNATIVE SYSTEM OF PARENTERAL DELIVERY: NASAL DRUG DELIVERY SYSTEM.

In modern pharmaceutics, the nose had been considered primarily as a route for local drug delivery. Nasal drug delivery for systemic effects has been practiced since ancient times. Nose is the important part of body for inhalation process. But when it is used as the route of drug delivery, attained the great attraction for various drugs because nose provides faster and higher level of drug absorption with possibility of self-administration.  Hydrophobic and low molecular drugs can easily penetrate through nasal mucosa with less degradation. Fast absorption can be achieved due to large absorption surface area and high vascularisation. In emergency nasal route can be used as alternative route of parenteral. This review provide an overview of the complete information about nasal drug delivery system such as anatomy and of nose, advantage, limitations, mechanism of drug absorption, factors affecting of nasal drug delivery, absorption improvement aspects, types of nasal drug delivery system and evaluation of nasal drug delivery system. KEYWORDS: Nose, Parenteral, Nasal Delivery, Absorption