Нейроглиальный комплекс префронтальной коры мозга мужчин и женщин в старческом возрасте

The aim of study was to investigate the neuroglial complex of the prefrontal cortex BA10 area in men and women of the senile age in comparison with the similar parameters in the elderly people. Material and methods. The study of the neuroglial complex was carried out on a series of frontal total sections of 5 male and 5 female brains in people of the senile age. Totally 20 male and female brain hemispheres were studied. The material was obtained no later than 24 hours after death and was fixed in 10% formalin solution. 20-micron-thick samples were stained with cresyl violet using Nissl method. The density of neurons, total glia, satellite gliocytes and neurons surrounded by them were investigated. Statistical data processing was performed in STATISTICA 12. Results. The study revealed gender age-related differences of the neuroglial complex morphometric parameters of the prefrontal cortex BA10 area in men and women. The decrease in the density of neurons, the proportion of satellite glia, the increase in the density of total glia were more significantly expressed in senile men than in senile women. These changes were more pronounced in the left hemisphere of the male brain and equally pronounced in both hemispheres in the female brain. Conclusion . Thus, this study detected features of the neuroglial complex of the prefrontal cortex BA10 area in men and women of the senile age. There was revealed the more significant decrease in the density of pyramidal neurons and satellite gliocytes in the cytoarchitectonic layer III of the prefrontal cortex BA10 area of the male brain compared with the similar layer of the female brain.