Synthesis of RWJ 68354: A potent inhibitor of the MAP kinase p38

James R. Henry,John H. Dodd

Synthesis of RWJ 68354: A potent inhibitor of the MAP kinase p38

1998

James R. Henry
John H. Dodd

Abstract The regiospecific synthesis of RWJ 68354, a potent inhibitor of the p38 MAP kinase, via a variation of the Bischler-Mo¨hlau indole synthesis is reported.

Keywords:

Mitogen-activated protein kinase
Combinatorial chemistry
Indole synthesis
Stereochemistry
Chemistry
p38 mitogen-activated protein kinases

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